This is about estrogen modulation, estrogen deficiency, and estrogen excess. See the general blog for the latest updates.
Signs of estrogen deficiency, estrogen receptor desensitization or lowered estrogen response include hot-flashes, hirsutism, alcopecia and itchy skin. High body temperature typically occurs with hot-flashes. Estrogen deficiency is commonly associated with polycystic ovarian syndrome (PCOS), high luteinizing hormone (LH) and insulin insensitivity.
Estrogen deficiency program blog
For a personal program of increasing estrogen and estrogen response, see hirsutism.
Signs of estrogen excess can include headache, low body temperature and heavy menstruation. Endometriosis is a concern of excess estrogen.
Receptor and enzyme modulation
From anecdoctal evidence, it seems that when aromatase enzymes, estrogen receptors or androgen receptors are sensitized in the presence of androgenic (testosterone) prominence, estrogen deficiency symptoms increase.
Aromatase is the conversion of androgens, with the exception of DHT, into estrogens.
It happens that aromatase enzymes occur in tissue where Estrogen Receptors alpha (α) and beta (β) are present. This cellular tissue includes: ovaries, corpus luteum, uterus, breast, adrenal glands, liver, skin, muscle, bone and fatty tissue. The capability for androgen conversion into estrogen in granulosa cells within the ovaries is very important for reproductive health.
Mint is recognized as an aromtase inhibitor that reduces estrogen conversion capacity when used in large amounts. In small amounts, however, mint has the ability to increase aromatase. This is expected for other aromatase inhibitors. It is possible that small amounts of other aromatase inhibitors upregulate aromatase enzymes.
Follicle stimulating hormone (FSH) in small amounts increases aromatase synthesis. Estrogen and FSH together develop the follicle during the first half of the menstrual cycle. Estrogen, inhibitin and luteinizing inhibitor (LI) together have their roles on the follicle during menstruation and proliferative phase.
Estrogen receptor modulation
It seems that estrogen receptor, especially ERβ, upregulation during a heavy balance of androgens increases androgenic imbalance further.
DHT is a strong hormone that downregulates androgen receptors. Surprisingly, in small amounts, androgens, including DHT, can resensitize aromatase enzymes in mammals (unlike in birds and in fish), but this outcome is likely conditional.
Breast enhancement; health blog
Blog updates: breast topics and health related content.
- Modulation of Aromatase by Phytoestrogens. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699002/.
- Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptors. https://www.ncbi.nlm.nih.gov/pubmed/19129512.
- The endocrinology of the menstrual cycle. https://www.ncbi.nlm.nih.gov/pubmed/24782009.
- Ovarian follicular and luteal physiology. https://www.ncbi.nlm.nih.gov/pubmed/6248477.
- Gonadotrophic control of follicular development and function during the oestrous cycle of the ewe. https://www.ncbi.nlm.nih.gov/pubmed/6300383.
- Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528347/.