Signs of estrogen deficiency include hot-flashes, hirsutism, alcopecia and itchy skin. Estrogen deficiency is commonly associated with polycystic ovarian syndrome (PCOS), high luteinizing hormone (LH) and insulin insensitivity.
Receptor and Enzyme Modulation
From anecdoctal evidence, it seems that when aromatase (conversion of androgens, with the exception of DHT, into estrogens) enzymes, estrogen receptors or androgen receptors are sensitized in the presence of andogenic prominence, estrogen deficiency symptoms increase.
It happens that aromatase enzymes occur in tissue where Estrogen Receptors alpha (α) and beta (β) are present. This cellular tissue includes: ovaries, corpus luteum, uterus, breast, adrenal glands, liver, skin, muscle, bone and fatty tissue. The capability for androgen conversion into estrogen in granulosa cells within the ovaries is very important for reproductive health.
Mint is recognized as an aromtase inhibitor that reduces estrogen conversion capacity when used in large amounts. In small amounts, however, mint has the ability to increase aromatase. This is expected for other aromatase inhibitors. It is possible that small amounts of other aromatase inhibitors upregulate aromatase enzymes.
Follicle stimulating hormone (FSH) in small amounts increases aromatase synthesis. Estrogen and FSH together develop the follicle during the first half of the menstrual cycle. Estrogen, inhibitin and luteinizing inhibitor (LI) together have their roles on the follicle during menstruation and proliferative phase.
DHT is a strong hormone that downregulates androgen receptors. Surprisingly, in small amounts, androgens, including DHT, can resensitize aromatase enzymes in mammals (unlike in birds and in fish), but this outcome is likely conditional.
It seems that estrogen receptor, especially ERβ, upregulation during a heavy balance of androgens increases androgenic imbalance further.
It seems that estrogen cream has different effects depending on when it is used. When there were signs of acne, estrogen cream has normalized body temperature, and increased estrogen response. When there were no signs of acne, estrogen cream only made body hair worse.
The effect of estrogen cream is similar to that of herbs that work on ERα and ERβ. A partial estrogenic response was sometimes caused, because an antagonist herb targeted ERα or ERβ. When acne was caused, an herb with an estrogen simile didn't always cause an estrogenic response, because that herb likely agonized a different estrogen receptor. In theory, herbs that caused acne sometimes possibly targeted one of the two estrogen receptors, and an estrogenic response depended on the specific receptor that estrogen simile targeted. It's possible that herbs that cause acne antagonize ERα or ERβ. When there's acne, it's possible that estrogen cream can cause both an estrogenic effect for estrogen receptors antagonized by acne and an androgenic effect for estrogen receptors not antagonized by acne.
Please note that the effects of estrogen cream are not throroughly proven. The effects of estrogen cream have also not been tested when there is bloating from progesterone either.
See precautions for more details of care to be taken with supplement use.
Estrogen deficiency program blog
For a personal program of increasing estrogen, see hirsutism. See the general blog for the latest updates.
Breast enhancement; health blog
Blog updates: breast topics and health related content.
- Modulation of Aromatase by Phytoestrogens. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699002/.
- Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptors. https://www.ncbi.nlm.nih.gov/pubmed/19129512.
- The endocrinology of the menstrual cycle. https://www.ncbi.nlm.nih.gov/pubmed/24782009.
- Ovarian follicular and luteal physiology. https://www.ncbi.nlm.nih.gov/pubmed/6248477.
- Gonadotrophic control of follicular development and function during the oestrous cycle of the ewe. https://www.ncbi.nlm.nih.gov/pubmed/6300383.